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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MELK
All Species:
14.55
Human Site:
Y143
Identified Species:
22.86
UniProt:
Q14680
Number Species:
14
Phosphosite Substitution
Charge Score:
0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q14680
NP_055606.1
651
74642
Y143
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
Chimpanzee
Pan troglodytes
XP_001168921
651
74605
Y143
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
Rhesus Macaque
Macaca mulatta
XP_001115076
651
74642
Y143
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
Dog
Lupus familis
XP_538730
651
74149
Y143
E
N
L
L
F
D
E
Y
H
K
L
K
L
I
D
Cat
Felis silvestris
Mouse
Mus musculus
Q61846
643
72695
N143
E
N
L
L
F
D
E
N
H
K
L
K
L
I
D
Rat
Rattus norvegicus
P54645
559
63955
K80
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509217
655
73776
D145
E
N
L
L
I
D
E
D
H
N
L
K
L
I
D
Chicken
Gallus gallus
NP_001026680
657
74208
E145
E
N
L
L
I
D
E
E
H
N
L
K
L
I
D
Frog
Xenopus laevis
NP_001081569
651
74289
D145
E
N
L
L
I
D
E
D
Q
N
L
K
L
I
D
Zebra Danio
Brachydanio rerio
Q6NSM8
1187
130949
N192
E
N
L
L
L
D
H
N
L
N
I
K
I
A
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_395000
606
68302
G127
V
A
Y
L
H
S
L
G
Y
A
H
R
D
L
K
Nematode Worm
Caenorhab. elegans
NP_001023420
703
79966
D143
E
N
L
L
L
T
E
D
L
H
L
K
L
I
D
Sea Urchin
Strong. purpuratus
XP_781767
971
109658
D419
E
N
L
L
L
D
E
D
Q
S
L
K
L
I
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q2V452
441
50581
Baker's Yeast
Sacchar. cerevisiae
P06782
633
72027
Y142
A
G
N
E
L
F
D
Y
I
V
Q
R
D
K
M
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.5
96.4
91.7
N.A.
83.4
29.6
N.A.
70.8
61.7
66.2
20.2
N.A.
N.A.
39.9
37.9
32.7
Protein Similarity:
100
99.5
97.5
95.8
N.A.
90.3
47.4
N.A.
80.1
75.9
80.3
34.1
N.A.
N.A.
55.7
56
45.5
P-Site Identity:
100
100
100
100
N.A.
93.3
0
N.A.
80
80
73.3
46.6
N.A.
N.A.
6.6
66.6
73.3
P-Site Similarity:
100
100
100
100
N.A.
93.3
13.3
N.A.
80
80
73.3
60
N.A.
N.A.
26.6
66.6
73.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
28.8
27
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
44.5
47.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
7
0
0
0
0
0
0
0
7
0
0
0
7
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
67
7
27
0
0
0
0
14
0
74
% D
% Glu:
74
0
7
7
0
0
67
7
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
34
7
0
0
0
7
0
0
0
0
0
% F
% Gly:
0
7
0
0
0
0
0
7
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
7
0
7
0
47
7
7
7
0
7
0
% H
% Ile:
0
0
0
7
20
0
0
0
7
0
7
0
7
67
7
% I
% Lys:
0
0
0
0
0
0
0
7
0
34
0
74
0
7
7
% K
% Leu:
0
0
74
80
27
0
14
0
20
0
67
0
67
7
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% M
% Asn:
0
74
7
0
0
7
0
14
0
27
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% P
% Gln:
0
0
0
0
7
0
0
0
14
0
7
0
0
0
0
% Q
% Arg:
7
7
0
0
0
0
0
0
0
0
7
14
0
0
0
% R
% Ser:
0
0
0
0
0
7
0
0
0
7
0
0
0
0
0
% S
% Thr:
0
0
0
0
0
7
0
0
0
0
0
0
0
0
0
% T
% Val:
7
0
0
0
0
0
0
0
0
7
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
7
0
0
0
0
34
7
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _